Natasha was signed to Orfanato Music Group for a few songs. She released a song featuring Don Omar, called "Dutty Love" and "Crazy in Love" with Farruko. Its success led to another collaboration with Omar. In 2017, she released the single "Criminal", with Ozuna, which became an instant hit. Becky G released "Sin Pijama" in collaboration with Natasha in April 2018. The song was Natasha's second hit. She released her debut album, Iluminatti on February 15, 2019, by Pina Records and Sony Music Latin. In 2019, She collaborated with Daddy Yankee, the Jonas Brothers and Sebastián Yatra on the song "Runaway".